At present, There's two types of reports on itaconate: Irg1?/? macrophages plus the regulatory effect of itaconate derivatives. These two outcomes had been complementary and exposed the regulatory mechanisms of itaconate associated alkylation on Keap1 to activate Nrf2, succinate dehydrogenase inhibition, activating transcription variable 3 (ATF3) i
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Abstract Oridonin, being a pure terpenoids located in traditional Chinese herbal medicine Isodon rubescens (Hemsl.) H.Hara, is extensively present in several Chinese medication preparations. The objective of this critique concentrates on giving the most up-to-date and in depth information on the pharmacology, pharmacokinetics and toxicity of oridon